Critical appraisal of Monkeypox (Mpox) in Africa using scoping and systematic review methods

Abdul-Azeez A. Anjorin(1), Ismail A. Odetokun(2), Oluwaseyi S. Ashaka(3), Temitope O. Fadipe(4), Aliyu Muhammed(5), Temitope O. Sogbanmu(6), Jean B. Nyandwi(7), Oyewale M. Morakinyo(8), Akeem B. Dauda(9), Mutiat A. Adetona(10), Sodiq O. Tijani(11), Wasiu O. Salami(12), Murtala B. Isah(13), George Gachara(14), Abdulazeez O. Giwa(15), Mohammed Lounis(16), Aala M. Maisara(17), Ezekiel F. Hallie(18), Ismail O. Adesanya(19), Rasha Mosbah(20), Kingsley N Ukwaja(21), Mohammed A. Ibrahim(22),


(1) Lagos State University Ojo, Nigeria & Nigerian Young Academy (NYA)
(2) University of Ilorin & Nigerian Young Academy (NYA)
(3) Caleb University, Imota, Nigeria
(4) Federal Institute of Industrial Research, Oshodi, Nigeria
(5) Ahmadu Bello University, Zaria & Nigeria Young Academy (NYA)
(6) University of Lagos, Lagos, Nigeria & Nigeria Young Academy (NYA)
(7) University of Rwanda, Kigali, Rwanda & East African Community Regional Centre of Excellence for Vaccines, Immunization and Health Supply Chain Management, Kigali, Rwanda
(8) University of Ibadan, Ibadan, Nigeria & Nigeria Young Academy (NYA)
(9) Federal University Dutsin-Ma, Dutsin-Ma, Nigeria & Nigeria Young Academy
(10) University of Ilorin, Nigeria
(11) College of Medicine, University of Lagos, Idi-Araba, Nigeria.
(12) Lagos State University Ojo, Nigeria
(13) Umaru Musa Yar'adua University, Katsina, Nigeria & Yobe State University, Damaturu, Nigeria
(14) Kenyatta University, Nairobi, Kenya.
(15) Lagos State University, Ojo, Nigeria
(16) University of Lagos, Lagos, Nigeria & University of Rwanda, Kigali, Rwanda.
(17) Ministry of Health, Khartoum, Sudan. International University of Africa, Sudan.
(18) University of Liberia
(19) US Army Reserve & Hospitalist, Bayou City Physicians, Spring, Texas, United States of America.
(20) Zagazig University Hospitals, Sharqia44519, Egypt & Military Medical Academy, Cairo, 11774, Egypt.
(21) Ebonyi State University, Abakaliki, Nigeria & David Umahi Federal University of Health Sciences, Uburu, Nigeria
(22) Ahmadu Bello University, Zaria
Corresponding Author

Abstract


Africa remains a battlefield for the emergence and re-emergence of deadly aetiologies including the Lassa fever virus from 1969, Monkey pox (mpox) virus from 1970, and Ebola virus from 1976 till date, among others. With the recent index case of mpox following rapid spread from Africa to different continents, a critical appraisal of the disease to x-ray its dynamics in Africa is warranted. This study integrated a mix of scoping and systematic reviews to converse the epidemiology and biosecurity/environmental issues from one health perspective. Our scoping review used major scientific databases based on their relevance and reliability, while the PROSPERO-registered systematic review followed the PRISMA guidelines. Phylogeny analysis was performed to compare recent outbreaks of mpox with the existing genotypic information. The genetic analysis focused on the H3L gene that codes for envelope proteins involved in viral attachment. Transmission of mpox virus was reported mainly in four routes. Animals implicated include monkeys, squirrels, and pigs. Risk factors include age, gender, occupation, climate, travel, political instability, and vaccination status. Different circulating strains were reported with eight-point mutations found to occur in Africa. Observed clustering within the predominant West African (WA) clade and the recent outbreak strains corroborate the reports of WA clade in other non-African and non-endemic countries. Viral adaptation in the WA clade enhanced person-to-person transmissibility, spreading to over 100 countries. Hence, there is need to address mpox host-associated physiological and biochemical changes, the development of mpox virus-specific diagnostic kits and vaccines, and studies on the disease's socio-ecological, economic and psychological consequences.

 


Keywords


Monkey pox virus, Africa, epidemiology, one health

References


Anjorin AA, Odetokun IA, Nyandwi JB, Elnadi H, Awiagah KS, Eyedo J, Abioye AI, Gachara G, Maisara AM, Razouqi Y, Yusuf Mohamud MF, Mhgoob ZE, Ajayi T, Ntirenganya L, Saibu M, Salako BL, Elelu N, Wright KO, Fasina FO, & Mosbah R (2022). Public Health Surveillance for Adverse Events Following COVID-19 Vaccination in Africa. Vaccines 10(4), 546. DOI: 10.3390/vaccines10040546.

WHO (2023). Mpox update. WHO, Geneva, Switzerland. https://worldhealthorg.shinyapps.io/mpx_global/

McCollum AM & Damon IK. Human monkeypox. Clinical infectious diseases. 2014;58(2):260-7.

Olumade TJ, Adesanya OA, Fred-Akintunwa IJ, Babalola DO, Oguzie JU, & Ogunsanya OA, et al. Infectious disease outbreak preparedness and response in Nigeria: history, limitations and recommendations for global health policy and practice. AIMS Public Health. 2020;7(4):736.

Breman JG, Ruti K, Steniowski M, Zanotto E, Gromyko A, & Arita I, et al. Human monkeypox 1970-1979/by JG Bremen, Kalisa-Ruti, MV Steniowski, E. Zanotto, AI Gromyko and I. Arita. 1980.

Yinka-Ogunleye A, Aruna O, Ogoina D, Aworabhi N, Eteng W, & Badaru S, et al. Reemergence of human monkeypox in Nigeria, 2017. Emerging infectious diseases. 2018;24(6):1149.

Brown K & Leggat PA. Human monkeypox: current state of knowledge and implications for the future. Tropical medicine and infectious disease. 2016;1(1):8.

Rimoin AW, Mulembakani PM, Johnston SC, Lloyd Smith JO, Kisalu NK, & Kinkela TL, et al. Major increase in human monkeypox incidence 30 years after smallpox vaccination campaigns cease in the Democratic Republic of Congo. Proceedings of the National Academy of Sciences. 2010;107(37):16262-7.

Berthet N, Descorps-Declère S, Besombes C, Curaudeau M, Nkili Meyong AA, & Selekon B, et al. Genomic history of human mpox infections in the Central African Republic between 2001 and 2018. Scientific reports. 2021;11(1):1-11.

Yinka-Ogunleye A, Aruna O, Dalhat M, Ogoina D, McCollum A, & Disu Y, et al. Outbreak of human monkeypox in Nigeria in 2017–18: a clinical and epidemiological report. The Lancet Infectious Diseases. 2019;19(8):872-9.

Sadeuh-Mba SA, Yonga MG, Els M, Batejat C, Eyangoh S, & Caro V, et al. Monkeypox virus phylogenetic similarities between a human case detected in Cameroon in 2018 and the 2017-2018 outbreak in Nigeria. Infection, Genetics and Evolution. 2019;69:8-11.

Reynolds MG, Wauquier N, Li Y, Satheshkumar PS, Kanneh LD, & Monroe B, et al. Human monkeypox in Sierra Leone after 44-Year absence of reported cases. Emerging Infectious Diseases. 2019;25(5):1023.

Reynolds MG, Carroll DS, Olson VA, Hughes C, Galley J, & Likos A, et al. A silent enzootic of an orthopoxvirus in Ghana, West Africa: evidence for multi-species involvement in the absence of widespread human disease. The American journal of tropical medicine and hygiene. 2010;82(4):746.

Radonić A, Metzger S, Dabrowski PW, Couacy-Hymann E, Schuenadel L, & Kurth A, et al. Fatal monkeypox in wild-living sooty mangabey, Cote d’Ivoire, 2012. Emerging Infectious Diseases. 2014;20(6):1009.

Durski KN, McCollum AM, Nakazawa Y, Petersen BW, Reynolds MG, & Briand S, et al. Emergence of monkeypox—west and central Africa, 1970–2017. Morbidity and mortality weekly report. 2018;67(10):306.

Mauldin MR, McCollum AM, Nakazawa YJ, Mandra A, Whitehouse ER, & Davidson W, et al. Exportation of monkeypox virus from the African continent. The Journal of infectious diseases. 2022;225(8):1367-76.

Erez N, Achdout H, Milrot E, Schwartz Y, Wiener-Well Y, & Paran N, et al. Diagnosis of imported monkeypox, Israel, 2018. Emerging infectious diseases. 2019;25(5):980.

Yong SEF, Ng OT, Ho ZJM, Mak TM, Marimuthu K, & Vasoo S, et al. Imported Monkeypox, Singapore. Emerging infectious diseases. 2020;26(8):1826.

Hobson G, Adamson J, Adler H, Firth R, Gould S, & Houlihan C, et al. Family cluster of three cases of monkeypox imported from Nigeria to the United Kingdom, May 2021. Eurosurveillance. 2021;26(32):2100745.

Rao AK, Schulte J, Chen T-H, Hughes CM, Davidson W, & Neff JM, et al. Monkeypox in a Traveler Returning from Nigeria—Dallas, Texas, July 2021. Morbidity and Mortality Weekly Report. 2022;71(14):509.

Kraemer MU, Tegally H, Pigott DM, Dasgupta A, Sheldon J, & Wilkinson E, et al. Tracking the 2022 monkeypox outbreak with epidemiological data in real-time. The Lancet Infectious Diseases. 2022.

Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, & Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. Systematic reviews. 2021;10(1):1-11.

Ouzzani M, Hammady H, Fedorowicz Z, & Elmagarmid A. Rayyan—a web and mobile app for systematic reviews. Systematic reviews. 2016;5(1):1-10.

Katoh K, Rozewicki J, & Yamada KD. MAFFT online service: multiple sequence alignment, interactive sequence choice and visualization. Briefings in bioinformatics. 2019;20(4):1160-6.

Tamura K, Nei M, & Kumar S. Prospects for inferring very large phylogenies by using the neighbor-joining method. Proceedings of the National Academy of Sciences. 2004;101(30):11030-5.

Jukes TH & Cantor CR. Evolution of protein molecules. Mammalian protein metabolism. 1969;3:21-132.

Saitou N & Nei M. The neighbor-joining method: a new method for reconstructing phylogenetic trees. Molecular biology and evolution. 1987;4(4):406-25.

Felsenstein J. Phylogenies from restriction sites: a maximum‐likelihood approach. Evolution. 1992;46(1):159-73.

Singh K, Gittis AG, Gitti RK, Ostazeski SA, Su H-P, & Garboczi DN. The vaccinia virus H3 envelope protein, a major target of neutralizing antibodies, exhibits a glycosyltransferase fold and binds UDP-glucose. Journal of Virology. 2016;90(10):5020-30.

Zhang Z, Schwartz S, Wagner L, & Miller W. A greedy algorithm for aligning DNA sequences. Journal of Computational biology. 2000;7(1-2):203-14.

Waterhouse AM, Procter JB, Martin DM, Clamp M, & Barton GJ. Jalview Version 2—a multiple sequence alignment editor and analysis workbench. Bioinformatics. 2009;25(9):1189-91.

Nei M & Kumar S. Molecular evolution and phylogenetics: Oxford University Press, USA; 2000.

Zuckerkandl E & Pauling L. Evolutionary divergence and convergence in proteins. Evolving genes and proteins: Elsevier; 1965. p. 97-166.

Kumar S, Stecher G, & Tamura K. MEGA7: molecular evolutionary genetics analysis version 7.0 for bigger datasets. Molecular biology and evolution. 2016;33(7):1870-4.

Alkhalil A, Hammamieh R, Hardick J, Ichou MA, Jett M, & Ibrahim S. Gene expression profiling of monkeypox virus-infected cells reveals novel interfaces for host-virus interactions. Virology Journal. 2010;7(1):1-19.

Lefkowitz EJ, Dempsey DM, Hendrickson RC, Orton RJ, Siddell SG, & Smith DB. Virus taxonomy: the database of the International Committee on Taxonomy of Viruses (ICTV). Nucleic acids research. 2018;46(D1):D708-D17.

Kabuga AI & El Zowalaty ME. A review of the monkeypox virus and a recent outbreak of skin rash disease in Nigeria. Journal of Medical Virology. 2019;91(4):533-40.

Likos AM, Sammons SA, Olson VA, Frace AM, Li Y, & Olsen-Rasmussen M, et al. A tale of two clades: monkeypox viruses. Journal of General Virology. 2005;86(10):2661-72.

Chen N, Li G, Liszewski MK, Atkinson JP, Jahrling PB, & Feng Z, et al. Virulence differences between monkeypox virus isolates from West Africa and the Congo basin. Virology. 2005;340(1):46-63.

Vanderplasschen A, Hollinshead M, & Smith GL. Intracellular and extracellular vaccinia virions enter cells by different mechanisms. Journal of General Virology. 1998;79(4):877-87.

McFadden G. Poxvirus tropism. Nature Reviews Microbiology. 2005;3(3):201-13.

Sodeik B & Krijnse-Locker J. Assembly of vaccinia virus revisited: de novo membrane synthesis or acquisition from the host? Trends in microbiology. 2002;10(1):15-24.

Manes NP, Estep RD, Mottaz HM, Moore RJ, Clauss TR, & Monroe ME, et al. Comparative proteomics of human monkeypox and vaccinia intracellular mature and extracellular enveloped virions. Journal of proteome research. 2008;7(3):960-8.

Hui DS & Zumla A. Severe acute respiratory syndrome: historical, epidemiologic, and clinical features. Infectious Disease Clinics. 2019;33(4):869-89.

Shchelkunov SN, Blinov VM, & Sandakhchiev LS. Ankyrin‐like proteins of variola and vaccinia viruses. FEBS letters. 1993;319(1-2):163-5.

Mosavi LK, Cammett TJ, Desrosiers DC, & Peng Zy. The ankyrin repeat as molecular architecture for protein recognition. Protein science. 2004;13(6):1435-48.

Hudson PN, Self J, Weiss S, Braden Z, Xiao Y, & Girgis NM, et al. Elucidating the role of the complement control protein in monkeypox pathogenicity. PloS one. 2012;7(4):e35086.

Song H, Josleyn N, Janosko K, Skinner J, Reeves RK, & Cohen M, et al. Monkeypox virus infection of rhesus macaques induces massive expansion of natural killer cells but suppresses natural killer cell functions. PloS one. 2013;8(10):e77804.

Johnston SC, Johnson JC, Stonier SW, Lin KL, Kisalu NK, & Hensley LE, et al. Cytokine modulation correlates with severity of monkeypox disease in humans. Journal of Clinical Virology. 2015;63:42-5.

Nagata N, Saijo M, Kataoka M, Ami Y, Suzaki Y, & Sato Y, et al. Pathogenesis of fulminant monkeypox with bacterial sepsis after experimental infection with West African monkeypox virus in a cynomolgus monkey. International Journal of Clinical and Experimental Pathology. 2014;7(7):4359.

Panning M, Asper M, Kramme S, Schmitz H, & Drosten C. Rapid detection and differentiation of human pathogenic orthopox viruses by a fluorescence resonance energy transfer real-time PCR assay. Clinical chemistry. 2004;50(4):702-8.

Parker S, Nuara A, Buller RML, & Schultz DA. Human monkeypox: an emerging zoonotic disease. 2007.

Alakunle E, Moens U, Nchinda G, & Okeke MI. Monkeypox virus in Nigeria: infection biology, epidemiology, and evolution. Viruses. 2020;12(11):1257.

Li Y, Olson VA, Laue T, Laker MT, & Damon IK. Detection of monkeypox virus with real-time PCR assays. Journal of Clinical Virology. 2006;36(3):194-203.

Ren J, Ye F, Zhao L, Guan Q, Zhao Y, & Song J, et al. Serological assay to detect human antibodies against mpoxvirus. Chinese Journal of Experimental and Clinical Virology. 2018:636-9.

Islam MR, Hossain MJ, Roy A, Hasan AN, Rahman MA, & Shahriar M, et al. Repositioning potentials of smallpox vaccines and antiviral agents in monkeypox outbreak: a rapid review on comparative benefits and risks. Health Science Reports. 2022;5(5):e798.

Nguyen P-Y, Ajisegiri WS, Costantino V, Chughtai AA, & MacIntyre CR. Reemergence of human monkeypox and declining population Immunity in the context of urbanization, Nigeria, 2017–2020. Emerging Infectious Diseases. 2021;27(4):1007.

Petersen BW, Damon IK, Pertowski CA, Meaney-Delman D, Guarnizo JT, & Beigi RH, et al. Clinical guidance for smallpox vaccine use in a postevent vaccination program. Morbidity and Mortality Weekly Report: Recommendations and Reports. 2015;64(2):1-26.

Hatch GJ, Graham VA, Bewley KR, Tree JA, Dennis M, & Taylor I, et al. Assessment of the protective effect of Imvamune and Acam2000 vaccines against aerosolized monkeypox virus in cynomolgus macaques. Journal of virology. 2013;87(14):7805-15.

Keckler MS, Salzer JS, Patel N, Townsend MB, Nakazawa YJ, & Doty JB, et al. IMVAMUNE® and ACAM2000® provide different protection against disease when administered postexposure in an intranasal monkeypox challenge prairie dog model. Vaccines. 2020;8(3):396.

Garza NL, Hatkin JM, Livingston V, Nichols DK, Chaplin PJ, & Volkmann A, et al. Evaluation of the efficacy of modified vaccinia Ankara (MVA)/IMVAMUNE® against aerosolized rabbitpox virus in a rabbit model. Vaccine. 2009;27(40):5496-504.

Petersen BW, Kabamba J, McCollum AM, Lushima RS, Wemakoy EO, & Tamfum J-JM, et al. Vaccinating against monkeypox in the Democratic Republic of the Congo. Antiviral research. 2019;162:171-7.

Adler H, Gould S, Hine P, Snell LB, Wong W, & Houlihan CF, et al. Clinical features and management of human monkeypox: a retrospective observational study in the UK. The Lancet Infectious Diseases. 2022.

Stittelaar KJ, Neyts J, Naesens L, Van Amerongen G, Van Lavieren RF, & Holý A, et al. Antiviral treatment is more effective than smallpox vaccination upon lethal monkeypox virus infection. Nature. 2006;439(7077):745-8.

Russo AT, Berhanu A, Bigger CB, Prigge J, Silvera PM, & Grosenbach DW, et al. Co-administration of tecovirimat and ACAM2000™ in non-human primates: Effect of tecovirimat treatment on ACAM2000 immunogenicity and efficacy versus lethal monkeypox virus challenge. Vaccine. 2020;38(3):644-54.

Berhanu A, Prigge JT, Silvera PM, Honeychurch KM, Hruby DE, & Grosenbach DW. Treatment with the smallpox antiviral tecovirimat (ST-246) alone or in combination with ACAM2000 vaccination is effective as a postsymptomatic therapy for monkeypox virus infection. Antimicrobial agents and chemotherapy. 2015;59(7):4296-300.

Hulme PE. One Biosecurity: A unified concept to integrate human, animal, plant, and environmental health. Emerging Topics in Life Sciences. 2020;4(5):539-49.

Woolaston K, Nay Z, Baker ML, Brockett C, Bruce M, & Degeling C, et al. An argument for pandemic risk management using a multidisciplinary One Health approach to governance: an Australian case study. Globalization and Health. 2022;18(1):1-12.

Change IPOC. Report of the nineteenth session of the intergovernmental panel on climate change (IPCC) Geneva, 17-20 (am only) April 2002. 2007.

Mills JN, Gage KL, & Khan AS. Potential influence of climate change on vector-borne and zoonotic diseases: a review and proposed research plan. Environmental health perspectives. 2010;118(11):1507-14.

Morens DM & Fauci AS. Emerging pandemic diseases: how we got to COVID-19. Cell. 2020;182(5):1077-92.

Alimi W, Bernstein A, Epstein J, Espinal M, Kakkar M, & Kochevar D, et al. Report of the scientific task force on preventing pandemics. Cambridge, MA: Harvard Chan C-CHANGE and Harvard Global Health Institute. 2021.

Mandja BA, Handschumacher P, Bompangue D, Gonzalez JP, Muyembe JJ, & Sauleau EA, et al. Environmental drivers of monkeypox transmission in the Democratic Republic of Congo. EcoHealth. 2022;19(3):354-64.

Hutin Y, Williams RJ, Malfait P, Pebody R, Loparev VN, & Ropp SL, et al. Outbreak of human monkeypox, Democratic Republic of Congo, 1996 to 1997. Emerging infectious diseases. 2001;7(3):434.

Doty JB, Malekani JM, Kalemba LN, Stanley WT, Monroe BP, & Nakazawa YU, et al. Assessing monkeypox virus prevalence in small mammals at the human–animal interface in the Democratic Republic of Congo. Viruses. 2017;9(10):283.

Marennikova S, Šeluhina EM, Mal'Ceva N, Čimiškjan K, & Macevič G. Isolation and properties of the causal agent of a new variola-like disease (monkeypox) in man. Bulletin of the World Health Organization. 1972;46(5):599.

Shchelkunov SN, Marennikova SS, & Moyer RW. Orthopoxviruses pathogenic for humans: Springer Science & Business Media; 2006.

Nakazawa Y, Emerson GL, Carroll DS, Zhao H, Li Y, & Reynolds MG, et al. Phylogenetic and ecologic perspectives of a monkeypox outbreak, southern Sudan, 2005. Emerging infectious diseases. 2013;19(2):237.

Kugelman JR, Johnston SC, Mulembakani PM, Kisalu N, Lee MS, & Koroleva G, et al. Genomic variability of monkeypox virus among humans, Democratic Republic of Congo. Emerging infectious diseases. 2014;20(2):232.

Nolen LD, Osadebe L, Katomba J, Likofata J, Mukadi D, & Monroe B, et al. Introduction of monkeypox into a community and household: risk factors and zoonotic reservoirs in the Democratic Republic of Congo. The American Journal of Tropical Medicine and Hygiene. 2015;93(2):410.

Quiner CA, Moses C, Monroe BP, Nakazawa Y, Doty JB, & Hughes CM, et al. Presumptive risk factors for monkeypox in rural communities in the Democratic Republic of Congo. PloS one. 2017;12(2):e0168664.

Doshi RH, Guagliardo SAJ, Dzabatou-Babeaux A, Likouayoulou C, Ndakala N, Moses C, et al. Strengthening of surveillance during monkeypox outbreak, Republic of Congo, 2017. Emerging Infectious Diseases. 2018;24(6):1158.

Stolka KB, Ngoyi BF, Grimes KE, Hemingway-Foday JJ, Lubula L, & Nzanzu Magazani A, et al. Assessing the surveillance system for priority zoonotic diseases in the Democratic Republic of Congo, 2017. Health security. 2018;16(S1):S-44-S-53.

Jezek Z, Arita I, Mutombo M, Dunn C, Nakano J, & Szczeniowski M. Four generations of probable person-to-person transmission of human monkeypox. American journal of epidemiology. 1986;123(6):1004-12.

Khodakevich L, Ježek Z, & Kinzanzka K. Isolation of monkeypox virus from wild squirrel infected in nature. Isolation of monkeypox virus from wild squirrel infected in nature. 1986(Jan. 11):98-9.

Formenty P, Muntasir MO, Damon I, Chowdhary V, Opoka ML, & Monimart C, et al. Human monkeypox outbreak caused by novel virus belonging to Congo Basin clade, Sudan, 2005. Emerging infectious diseases. 2010;16(10):1539.

Bertherat E, Thullier P, Shako JC, England K, Koné M-L, & Arntzen L, et al. Lessons learned about pneumonic plague diagnosis from 2 outbreaks, Democratic Republic of the Congo. Emerging Infectious Diseases. 2011;17(5):778.

Eshoo MW, Whitehouse CA, Nalca A, Zoll S, Ecker JA, & Hall TA, et al. Rapid and high-throughput pan-Orthopoxvirus detection and identification using PCR and mass spectrometry. PLoS One. 2009;4(7):e6342.

Levine RS, Peterson AT, Yorita KL, Carroll D, Damon IK, & Reynolds MG. Ecological niche and geographic distribution of human monkeypox in Africa. PloS one. 2007;2(1):e176.

Whitehouse ER, Bonwitt J, Hughes CM, Lushima RS, Likafi T, & Nguete B, et al. Clinical and epidemiological findings from enhanced monkeypox surveillance in Tshuapa province, Democratic Republic of the Congo during 2011–2015. The Journal of infectious diseases. 2021;223(11):1870-8.

Lourie B, Nakano JH, Kemp GE, & Setzer HW. Isolation of poxvirus from an African Rodent. Journal of infectious diseases. 1975;132(6):677-81.

Thomassen HA, Fuller T, Asefi-Najafabady S, Shiplacoff JA, Mulembakani PM, & Blumberg S, et al. Pathogen-host associations and predicted range shifts of human monkeypox in response to climate change in central Africa. PLoS One. 2013;8(7):e66071.

Arita I & Henderson D. Smallpox and monkeypox in non-human primates. Bulletin of the World Health Organization. 1968;39(2):277.

Tom-Aba D, Silenou BC, Doerrbecker J, Fourie C, Leitner C, & Wahnschaffe M, et al. The Surveillance Outbreak Response Management and Analysis System (SORMAS): digital health global goods maturity assessment. JMIR Public Health and Surveillance. 2020;6(2):e15860.

Parker S & Buller RM. A review of experimental and natural infections of animals with monkeypox virus between 1958 and 2012. Future virology. 2013;8(2):129-57.

Gispen R, Brand-Saathof B, & Hekker A. Monkeypox-specific antibodies in human and simian sera from the Ivory Coast and Nigeria. Bulletin of the World Health Organization. 1976;53(4):355.

Jayswal S & Kakadiya J. A narrative review of pox: smallpox vs monkeypox. The Egyptian Journal of Internal Medicine. 2022;34(1):90.

Feng Y, Zhang Y, Liu S, Guo C, Wang W, & Zhang W, et al. Unexpectedly higher levels of naturally occurring anti-Orthopoxvirus neutralizing antibodies are observed among gay men than general adult population. medRxiv. 2022:2022.12. 20.22283644.

Learned LA, Reynolds MG, Wassa DW, Li Y, Olson VA, & Karem K, et al. Extended interhuman transmission of monkeypox in a hospital community in the Republic of the Congo, 2003. The American journal of tropical medicine and hygiene. 2005;73(2):428-34.

Hendrickson RC, Wang C, Hatcher EL, & Lefkowitz EJ. Orthopoxvirus genome evolution: the role of gene loss. Viruses. 2010;2(9):1933-67.

Simmonds P, Aiewsakun P, & Katzourakis A. Prisoners of war—host adaptation and its constraints on virus evolution. Nature Reviews Microbiology. 2019;17(5):321-8.

Werden SJ, Rahman MM, & McFadden G. Poxvirus host range genes. Advances in virus research. 2008;71:135-71.

Emerson GL, Li Y, Frace MA, Olsen-Rasmussen MA, Khristova ML, & Govil D, et al. The phylogenetics and ecology of the orthopoxviruses endemic to North America. PloS one. 2009;4(10):e7666.

Luna N, Ramírez AL, Muñoz M, Ballesteros N, Patiño LH, & Castañeda SA, et al. Phylogenomic analysis of the monkeypox virus (MPOXV) 2022 outbreak: Emergence of a novel viral lineage? Travel medicine and infectious disease. 2022;49:102402.

Zandi M, Adli AH, & Shafaati M. Comments on “Diagnosis of monkeypox virus–An overview”. Travel Medicine and Infectious Disease. 2022.

Altindis M, Puca E, & Shapo L. Diagnosis of monkeypox virus–An overview. Travel medicine and infectious disease. 2022:102459.

McCarthy MW. Recent advances in the diagnosis monkeypox: implications for public health. Expert Review of Molecular Diagnostics. 2022;22(7):739-44.

Molteni C, Forni D, Cagliani R, Mozzi A, Clerici M, & Sironi M. Evolution of the orthopoxvirus core genome. Virus Research. 2023; 323:198975.

Breman JG. Monkeypox: an emerging infection for humans? Emerging infections 4. 2000:45-67.

Reed KD, Melski JW, Graham MB, Regnery RL, Sotir MJ, & Wegner MV, et al. The detection of monkeypox in humans in the Western Hemisphere. New England Journal of Medicine. 2004;350(4):342-50.

Sundberg JP & Schofield PN. One medicine, one pathology, and the one health concept. Journal of the American Veterinary Medical Association. 2009;234(12):1530-1.

Control CfD, Prevention. Monkeypox and smallpox vaccine guidance. Ultimo aggiornamento. 2022;2.

Douglass NJ. Molecular and evolutionary analysis of a gene conserved in most Orthopoxviruses. 1993.

Saijo M, Ami Y, Suzaki Y, Nagata N, Iwata N, & Hasegawa H, et al. Virulence and pathophysiology of the Congo Basin and West African strains of monkeypox virus in non-human primates. Journal of general virology. 2009;90(9):2266-71.

Fuller T, Thomassen HA, Mulembakani PM, Johnston SC, Lloyd-Smith JO, & Kisalu NK, et al. Using remote sensing to map the risk of human monkeypox virus in the Congo Basin. EcoHealth. 2011; 8:14-25.

Li Y, Zhao H, Wilkins K, Hughes C, & Damon IK. Real-time PCR assays for the specific detection of monkeypox virus West African and Congo Basin strain DNA. Journal of virological methods. 2010;169(1):223-7.

Orba Y, Sasaki M, Yamaguchi H, Ishii A, Thomas Y, & Ogawa H, et al. Orthopoxvirus infection among wildlife in Zambia. Journal of General Virology. 2015;96(2):390-4.

Besombes C, Gonofio E, Konamna X, Selekon B, Gessain A, & Berthet N, et al. Intrafamily transmission of monkeypox virus, Central African Republic, 2018. Emerging infectious diseases. 2019;25(8):1602.

Kalthan E, Tenguere J, Ndjapou S, Koyazengbe T, Mbomba J, & Marada R, et al. Investigation of an outbreak of monkeypox in an area occupied by armed groups, Central African Republic. Medecine et maladies infectieuses. 2018;48(4):263-8.

Ye F, Song J, Zhao L, Zhang Y, Xia L, & Zhu L, et al. Molecular evidence of human monkeypox virus infection, Sierra Leone. Emerging Infectious Diseases. 2019;25(6):1220.

Patrono LV, Pléh K, Samuni L, Ulrich M, Röthemeier C, & Sachse A, et al. Monkeypox virus emergence in wild chimpanzees reveals distinct clinical outcomes and viral diversity. Nature Microbiology. 2020;5(7):955-65.

Hughes CM, Liu L, Davidson WB, Radford KW, Wilkins K, & Monroe B, et al. A tale of two viruses: coinfections of monkeypox and varicella zoster virus in the Democratic Republic of Congo. The American journal of tropical medicine and hygiene. 2021;104(2):604-11.

Peter OJ, Kumar S, Kumari N, Oguntolu FA, Oshinubi K, & Musa R. Transmission dynamics of Monkeypox virus: a mathematical modelling approach. Modeling Earth Systems and Environment. 2021:1-12.

Shchelkunov SN, Totmenin AV, Babkin IV, Safronov PF, Ryazankina OI, & Petrov NA, et al. Human monkeypox and smallpox viruses: genomic comparison. FEBS letters. 2001;509(1):66-70.

Ellis CK, Carroll DS, Lash RR, Peterson AT, Damon IK, & Malekani J, et al. Ecology and geography of human monkeypox case occurrences across Africa. Journal of wildlife diseases. 2012;48(2):335-47.

Ogoina D, Mohammed A, Yinka-Ogunleye A, & Ihekweazu C. A case of suicide during the 2017 monkeypox outbreak in Nigeria. IJID Regions. 2022; 3:226-7.


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DOI: 10.57046/MJCJ2507

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